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Review Series 10.1172/JCI124616

More friend than foe: the emerging role of neutrophils in tissue repair

Moritz Peiseler1,2 and Paul Kubes1,2,3

1Department of Pharmacology and Physiology,

2Snyder Institute for Chronic Diseases, and

3Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Address correspondence to: Paul Kubes, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. Phone: 403.220.2705; Email: pkubes@ucalgary.ca.

Find articles by Peiseler, M. in: JCI | PubMed | Google Scholar |

1Department of Pharmacology and Physiology,

2Snyder Institute for Chronic Diseases, and

3Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Address correspondence to: Paul Kubes, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. Phone: 403.220.2705; Email: pkubes@ucalgary.ca.

Find articles by Kubes, P. in: JCI | PubMed | Google Scholar

First published June 17, 2019 - More info

Published in Volume 129, Issue 7 on July 1, 2019
J Clin Invest. 2019;129(7):2629–2639. https://doi.org/10.1172/JCI124616.
© 2019 American Society for Clinical Investigation
First published June 17, 2019 - Version history

Neutrophils are the most abundant immune cells in humans and serve as first responders to a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules, neutrophils invade sites of inflammation to eradicate pathogens and clear debris. Traditionally, neutrophils were thought to cause collateral tissue damage before dying at the site. However, the presence of neutrophil infiltration into sterile injuries (in the absence of infections) suggests additional roles for these cells. Now, the view of neutrophils as indiscriminate killers seems to be changing as evolving evidence suggests that neutrophils actively orchestrate resolution of inflammation and contribute to tissue repair. Novel concepts include the idea that neutrophils are key to revascularization and subsequently reverse-transmigrate back to the vasculature, actively leaving sites of tissue damage to re-home to functional niches in the lung and bone marrow. This Review scrutinizes the role of neutrophils in tissue damage and repair, discussing recent findings and raising unresolved questions around this intriguing immune cell.

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