Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews...
    • Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
    • Reparative Immunology (Jul 2019)
    • Allergy (Apr 2019)
    • Biology of familial cancer predisposition syndromes (Feb 2019)
    • Mitochondrial dysfunction in disease (Aug 2018)
    • Lipid mediators of disease (Jul 2018)
    • Cellular senescence in human disease (Apr 2018)
    • View all review series...
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Scientific Show Stoppers
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • About
  • Editors
  • Consulting Editors
  • For authors
  • Current issue
  • Past issues
  • By specialty
  • Subscribe
  • Alerts
  • Advertise
  • Contact
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • Brief Reports
  • Technical Advances
  • Commentaries
  • Editorials
  • Hindsight
  • Review series
  • Reviews
  • The Attending Physician
  • First Author Perspectives
  • Scientific Show Stoppers
  • Top read articles
  • Concise Communication
Airway plumbing
John W. Hanrahan
John W. Hanrahan
Published May 15, 2000
Citation Information: J Clin Invest. 2000;105(10):1343-1344. https://doi.org/10.1172/JCI10088.
View: Text | PDF
Category: Commentary

Airway plumbing

  • Text
  • PDF
Abstract

Authors

John W. Hanrahan

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
Proposed mechanism for feedback regulation of ASL volume. (a) Evaporatio...
Proposed mechanism for feedback regulation of ASL volume. (a) Evaporation reduces ASL volume, reduces the efficiency of mucociliary clearance, and increases ASL osmolality. (b) High osmotic permeability of the apical membrane allows water to be drawn into the ASL to restore osmolality and causes the cells to shrink. Shrinkage of surface columnar cells triggers release of vasodilator substances such as nitric oxide (NO), which increase fluid delivery by subepithelial microvasculature.
Follow JCI:
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts