Banff human organ transplant transcripts correlate with renal allograft pathology and outcome: importance of capillaritis and subpathologic rejection
IA Rosales, GK Mahowald… - Journal of the …, 2022 - journals.lww.com
Background To seek insights into the pathogenesis of chronic active antibody–mediated
rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic
component scores and graft outcomes. Methods We utilized the NanoString nCounter
platform and the Banff Human Organ Transplant gene panel to quantify transcripts on 326
archived renal allograft biopsy samples. This system allowed correlation of transcripts with
Banff pathology scores from the same tissue block and correlation with long-term outcomes …
rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic
component scores and graft outcomes. Methods We utilized the NanoString nCounter
platform and the Banff Human Organ Transplant gene panel to quantify transcripts on 326
archived renal allograft biopsy samples. This system allowed correlation of transcripts with
Banff pathology scores from the same tissue block and correlation with long-term outcomes …