Memory T Lymphocytes Generated by Mycobacterium bovis BCG Vaccination Reside within a CD4 CD44lo CD62 Ligandhi Population
A Kipnis, S Irwin, AA Izzo, RJ Basaraba… - Infection and …, 2005 - Am Soc Microbiol
A Kipnis, S Irwin, AA Izzo, RJ Basaraba, IM Orme
Infection and immunity, 2005•Am Soc MicrobiolIn the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation
of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo (CD62Llo)
which were capable of secreting gamma interferon. Upon cell transfer, however, cells
expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the
recipients from a virulent challenge infection, suggesting the emergence of T-cell memory
from within this subset.
of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo (CD62Llo)
which were capable of secreting gamma interferon. Upon cell transfer, however, cells
expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the
recipients from a virulent challenge infection, suggesting the emergence of T-cell memory
from within this subset.
Abstract
In the lungs of mice vaccinated with Mycobacterium bovis BCG, there was an accumulation of CD4 cells expressing the activated effector phenotype CD44hi CD62 ligandlo (CD62Llo) which were capable of secreting gamma interferon. Upon cell transfer, however, cells expressing a resting/naïve phenotype (CD44lo CD62Lhi) were capable of protecting the recipients from a virulent challenge infection, suggesting the emergence of T-cell memory from within this subset.
American Society for Microbiology