Nax-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic acids to induce water intake in response to increases in [Na+] in …
Na x is a [Na+] sensor expressed in specific glial cells in the sensory circumventricular
organs (sCVOs) in the brain. We recently demonstrated that Na x signals are involved in the
control of not only salt intake but also water intake behavior. Our pharmacological
experiments suggested that Na x signals led to activation of neurons bearing TRPV4 by
using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake. In the
present study, we performed selective lesions of individual sCVOs in wild-type (WT) mice …
organs (sCVOs) in the brain. We recently demonstrated that Na x signals are involved in the
control of not only salt intake but also water intake behavior. Our pharmacological
experiments suggested that Na x signals led to activation of neurons bearing TRPV4 by
using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water intake. In the
present study, we performed selective lesions of individual sCVOs in wild-type (WT) mice …