The role of brain angiotensin in thirst and AVP release induced by hemorrhage
MI Phillips, F Heininger, S Toffolo - Regulatory peptides, 1996 - Elsevier
This study investigated the role of brain angiotensin (Ang II) in thirst induced by hemorrhage.
Hemorrhage by blood withdrawal from the femoral artery to 33% and 44% blood volume
loss produces a dose response increase in plasma Ang II. In the brainstem there was no
Ang II response to hemorrhage. In the hypothalamus, Brain Ang II was maximally elevated to
33% hemorrhage. Thus, plasma Ang II and brain Ang II had an independent response to
hemorrhage. To further test the role of central versus peripheral Ang II, we tested the effect of …
Hemorrhage by blood withdrawal from the femoral artery to 33% and 44% blood volume
loss produces a dose response increase in plasma Ang II. In the brainstem there was no
Ang II response to hemorrhage. In the hypothalamus, Brain Ang II was maximally elevated to
33% hemorrhage. Thus, plasma Ang II and brain Ang II had an independent response to
hemorrhage. To further test the role of central versus peripheral Ang II, we tested the effect of …