The challenge of HIV-1 subtype diversity
BS Taylor, ME Sobieszczyk… - … England Journal of …, 2008 - Mass Medical Soc
BS Taylor, ME Sobieszczyk, FE McCutchan, SM Hammer
New England Journal of Medicine, 2008•Mass Medical SocHIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of
new strains. This review discusses the implications of subtype diversity in HIV-1 for possible
differential rates of disease progression, responses to antiretroviral therapy (including the
development of resistance), and vaccine development.
classifiable into distinct subtypes needs to reflect the reality of the constant emergence of
new strains. This review discusses the implications of subtype diversity in HIV-1 for possible
differential rates of disease progression, responses to antiretroviral therapy (including the
development of resistance), and vaccine development.
HIV-1 has evolved multiple mechanisms to elude immune control. The view of virus as classifiable into distinct subtypes needs to reflect the reality of the constant emergence of new strains. This review discusses the implications of subtype diversity in HIV-1 for possible differential rates of disease progression, responses to antiretroviral therapy (including the development of resistance), and vaccine development.
The New England Journal Of Medicine