Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of
diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited
success. We extended previous efforts in three dimensions, examining a more
comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes
characterized for a wider range of cross-sectional diabetic kidney disease phenotypes. In
2843 subjects, we estimated that the heritability of diabetic kidney disease was 35%(P= 6.4× …