The HIF1α-PFKFB3 pathway: a key player in diabetic retinopathy
T Vezza, VM Víctor - The Journal of Clinical Endocrinology & …, 2021 - academic.oup.com
T Vezza, VM Víctor
The Journal of Clinical Endocrinology & Metabolism, 2021•academic.oup.comAbbreviations: ANGPT2, angiopoietin 2; CXCL12, CXC motif chemokine 12; DR, diabetic
retinopathy; HIF1α, hypoxiainducible factor 1α; NPDR, nonproliferative diabetic retinopathy;
OIR, O2-induced retinopathy model; PDGFB, platelet-derived growth factor B; PDR,
proliferative diabetic retinopathy; PFKFB3, 6-phosphofructo-2-kinase—fructose-2, 6-
bisphosphatase 3; PGF, placental growth factor; RAGEs, receptor for advanced glycation
end products; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor.
retinopathy; HIF1α, hypoxiainducible factor 1α; NPDR, nonproliferative diabetic retinopathy;
OIR, O2-induced retinopathy model; PDGFB, platelet-derived growth factor B; PDR,
proliferative diabetic retinopathy; PFKFB3, 6-phosphofructo-2-kinase—fructose-2, 6-
bisphosphatase 3; PGF, placental growth factor; RAGEs, receptor for advanced glycation
end products; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor.
Abbreviations: ANGPT2, angiopoietin 2; CXCL12, CXC motif chemokine 12; DR, diabetic retinopathy; HIF1α, hypoxiainducible factor 1α; NPDR, nonproliferative diabetic retinopathy; OIR, O2-induced retinopathy model; PDGFB, platelet-derived growth factor B; PDR, proliferative diabetic retinopathy; PFKFB3, 6-phosphofructo-2-kinase—fructose-2, 6-bisphosphatase 3; PGF, placental growth factor; RAGEs, receptor for advanced glycation end products; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor.
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