Genome-wide association study of diabetic kidney disease highlights biology involved in glomerular basement membrane collagen

RM Salem, JN Todd, N Sandholm… - Journal of the …, 2019 - journals.lww.com
Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk
remain largely unknown. Methods To identify genetic variants predisposing to diabetic
kidney disease, we performed genome-wide association study (GWAS) analyses. Through
collaboration with the Diabetes Nephropathy Collaborative Research Initiative, we
assembled a large collection of type 1 diabetes cohorts with harmonized diabetic kidney …