[HTML][HTML] Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
D Pejoski, C De Rham, P Martinez-Murillo, F Santoro… - npj Vaccines, 2020 - nature.com
npj Vaccines, 2020•nature.com
Abstract The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after
immunization, suggesting the contribution of innate immune responses. We report
modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30
surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages
and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between
the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine …
immunization, suggesting the contribution of innate immune responses. We report
modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30
surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages
and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between
the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine …
Abstract
The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.
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