The tumor-infiltrating myeloid cell compartment represents a heterogeneous population of
broadly immunosuppressive cells that have been exploited by the tumor to support its
growth. Their accumulation in tumor and secondary lymphoid tissue leads to the
suppression of antitumor immune responses and is thus a target for therapeutic intervention.
As it is known that the local cytokine milieu can dictate the functional programming of tumor-
infiltrating myeloid cells, strategies have been devised to manipulate the tumor …