Unmasking pancreatic cancer: epitope spreading after single antigen chimeric antigen receptor T-cell therapy in a human phase I trial
M Heckler, SK Dougan - Gastroenterology, 2018 - gastrojournal.org
T-cells engineered with antibody-like recognition domains, better known as CAR-Ts,
represent a promising treatment modality for cancer. Approval from the US Food and Drug
Administration for two CD19-directed CAR-T therapies has invigorated research in this area.
CD19 expression is restricted to normal B cells and B-cell leukemias, and is critical for
leukemic cell survival, making it a nearly perfect therapeutic target, which has been difficult
to emulate in solid tumors. Nevertheless, efforts to extend CAR-T technology to solid tumors …
represent a promising treatment modality for cancer. Approval from the US Food and Drug
Administration for two CD19-directed CAR-T therapies has invigorated research in this area.
CD19 expression is restricted to normal B cells and B-cell leukemias, and is critical for
leukemic cell survival, making it a nearly perfect therapeutic target, which has been difficult
to emulate in solid tumors. Nevertheless, efforts to extend CAR-T technology to solid tumors …