Numbers of long-term hematopoietic stem cells from bone marrow of fanca and fancc knockout mice can be greatly enhanced by their collection and processing in …
HE Broxmeyer, ML Capitano, S Cooper… - Blood Cells, Molecules …, 2021 - Elsevier
Fanconi anemia (FA) is associated with bone marrow failure. Bone marrow (BM) from
patients with FA and fanca−/− and fancc−/− mice are deficient in hematopoietic stem (HSCs)
and progenitor cells (HPCs). Decreased HSCs/HPCs compromise their use in human and
mouse hematopoietic cell transplantation (HCT) and gene therapy to correct genetic defects
causing FA. We reported increased collection of HSCs from mouse bone marrow and
mobilized peripheral blood, and human cord blood of normal donors after …
patients with FA and fanca−/− and fancc−/− mice are deficient in hematopoietic stem (HSCs)
and progenitor cells (HPCs). Decreased HSCs/HPCs compromise their use in human and
mouse hematopoietic cell transplantation (HCT) and gene therapy to correct genetic defects
causing FA. We reported increased collection of HSCs from mouse bone marrow and
mobilized peripheral blood, and human cord blood of normal donors after …
