[HTML][HTML] Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression …
JM Noto, KL Rose, AJ Hachey, AG Delgado… - Molecular & Cellular …, 2019 - ASBMB
Helicobacter pylori is the strongest risk factor for gastric cancer. Initial interactions between
H. pylori and its host originate at the microbial-gastric epithelial cell interface, and contact
between H. pylori and gastric epithelium activates signaling pathways that drive
oncogenesis. One microbial constituent that increases gastric cancer risk is the cag
pathogenicity island, which encodes a type IV secretion system that translocates the effector
protein, CagA, into host cells. We previously demonstrated that infection of Mongolian …
H. pylori and its host originate at the microbial-gastric epithelial cell interface, and contact
between H. pylori and gastric epithelium activates signaling pathways that drive
oncogenesis. One microbial constituent that increases gastric cancer risk is the cag
pathogenicity island, which encodes a type IV secretion system that translocates the effector
protein, CagA, into host cells. We previously demonstrated that infection of Mongolian …
