[HTML][HTML] A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function
M Zhou, L Xue, Y Chen, H Li, Q He, B Wang… - Journal of Biological …, 2018 - ASBMB
Defective nucleotide modifications of mitochondrial tRNAs have been associated with
several human diseases, but their pathophysiology remains poorly understood. In this
report, we investigated the pathogenic molecular mechanism underlying a hypertension-
associated 4435A→ G mutation in mitochondrial tRNA Met. The m. 4435A→ G mutation
affected a highly conserved adenosine at position 37, 3′ adjacent to the tRNA's anticodon,
which is important for the fidelity of codon recognition and stabilization. We hypothesized …
several human diseases, but their pathophysiology remains poorly understood. In this
report, we investigated the pathogenic molecular mechanism underlying a hypertension-
associated 4435A→ G mutation in mitochondrial tRNA Met. The m. 4435A→ G mutation
affected a highly conserved adenosine at position 37, 3′ adjacent to the tRNA's anticodon,
which is important for the fidelity of codon recognition and stabilization. We hypothesized …
