Importance The androgen receptor (AR) pathway is emerging as a potential therapeutic
target in breast cancer. To date, AR-targeted drugs have been approved only for treatment of
prostate cancer; however, AR-targeted treatment for breast cancer is an area of active
investigation. Through review of preclinical studies, retrospective clinical studies, and
clinical trials, we examined the biology of AR and AR-related pathways, the potential for AR-
targeted therapies in breast cancer, and potential biomarkers for AR-targeted treatments …