Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition

CH Heldin, M Landström, A Moustakas - Current opinion in cell biology, 2009 - Elsevier
CH Heldin, M Landström, A Moustakas
Current opinion in cell biology, 2009Elsevier
Members of the transforming growth factor-β (TGF-β) family have important roles during
embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their
cellular effects via binding to serine/threonine kinase receptors. Members of the Smad family
of transcription factors are important intracellular messengers, and recent studies have
shown that the ubiquitin ligase TRAF6 mediates other specific signals. TGF-β signaling is
tightly controlled by post-translational modifications, which regulate the activity, stability, and …
Members of the transforming growth factor-β (TGF-β) family have important roles during embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their cellular effects via binding to serine/threonine kinase receptors. Members of the Smad family of transcription factors are important intracellular messengers, and recent studies have shown that the ubiquitin ligase TRAF6 mediates other specific signals. TGF-β signaling is tightly controlled by post-translational modifications, which regulate the activity, stability, and subcellular localization of the signaling components. The aim of this review is to summarize some of the recent findings on the mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial–mesenchymal transition.
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