Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease

M Ioannou, T Alissafi, I Lazaridis, G Deraos… - The Journal of …, 2012 - journals.aai.org
The Journal of Immunology, 2012journals.aai.org
There is a need in autoimmune diseases to uncover the mechanisms involved in the natural
resolution of inflammation. In this article, we demonstrate that granulocytic myeloid-derived
suppressor cells (G-MDSCs) abundantly accumulate within the peripheral lymphoid
compartments and target organs of mice with experimental autoimmune encephalomyelitis
prior to disease remission. In vivo transfer of G-MDSCs ameliorated experimental
autoimmune encephalomyelitis, significantly decreased demyelination, and delayed …
Abstract
There is a need in autoimmune diseases to uncover the mechanisms involved in the natural resolution of inflammation. In this article, we demonstrate that granulocytic myeloid-derived suppressor cells (G-MDSCs) abundantly accumulate within the peripheral lymphoid compartments and target organs of mice with experimental autoimmune encephalomyelitis prior to disease remission. In vivo transfer of G-MDSCs ameliorated experimental autoimmune encephalomyelitis, significantly decreased demyelination, and delayed disease onset through inhibition of encephalitogenic Th1 and Th17 immune responses. Exposure of G-MDSCs to the autoimmune milieu led to up-regulation of the programmed death 1 ligand that was required for the G-MDSC–mediated suppressive function both in vitro and in vivo. Importantly, myeloid-derived suppressor cells were enriched in the periphery of subjects with active multiple sclerosis and suppressed the activation and proliferation of autologous CD4+ T cells ex vivo. Collectively, this study revealed a pivotal role for myeloid-derived suppressor cells in the regulation of multiple sclerosis, which could be exploited for therapeutic purposes.
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