[HTML][HTML] Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway

J Nakae, BC Park, D Accili - Journal of Biological Chemistry, 1999 - ASBMB
In the nematode Caenorhabditis elegans, mutations of the insulin/insulin-like growth factor-1
receptor homologue Daf-2 gene cause developmental arrest at the dauer stage. The effect
of Daf-2 mutations is counteracted by mutations in the Daf-16 gene, suggesting that Daf-16
is required for signaling by Daf-2. Daf-16 encodes a forkhead transcription factor. Based on
sequence similarity, the FKHR genes are the likeliest mammalian Daf-16 homologues.
FKHR proteins contain potential sites for phosphorylation by the serine/threonine kinase Akt …