[HTML][HTML] Regulation of inducible heparanase gene transcription in activated T cells by early growth response 1

AM de Mestre, LM Khachigian, FS Santiago… - Journal of Biological …, 2003 - ASBMB
Cleavage of heparan sulfate by the β-d-endoglucuronidase heparanase (HPSE) is a
fundamental event in a number of important physiological processes including inflammation,
wound healing, and angiogenesis. HPSE activity has also been directly correlated with
pathological conditions such as tumor growth and metastasis and autoimmune disease. The
tight regulation of HPSE expression and function is critical to ensure homeostasis of the
normal physiological processes to which it contributes and to prevent imbalance toward …