[HTML][HTML] CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis

I Moshkovits, D Shik, M Itan, D Karo-Atar… - Mucosal …, 2014 - Elsevier
Eosinophil accumulation in health and disease is a hallmark characteristic of mucosal
immunity and type 2 helper T cell (Th2) inflammation. Eotaxin-induced CCR3 (chemokine
(CC motif) receptor 3) signaling has a critical role in eosinophil chemotactic responses.
Nevertheless, the expressions of immunoreceptor tyrosine-based inhibitory motif-bearing
receptors such as CMRF35-like molecule-1 (CLM-1) and their ability to govern eosinophil
migration are largely unknown. We now report that CLM-1 (but not CLM-8) is highly and …