[HTML][HTML] Therapeutic promise and challenges of targeting DLL4/NOTCH1

M Yan - Vascular cell, 2011 - Springer
Vascular cell, 2011Springer
DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular
development and has emerged as an attractive target for angiogenesis-based cancer
therapies. However, newly reported toxicity findings raise safety concerns of chronic
pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs)
might offer insights into how to safely harness this important signaling pathway.
Abstract
DLL4-mediated NOTCH1 signaling represents an essential pathway for vascular development and has emerged as an attractive target for angiogenesis-based cancer therapies. However, newly reported toxicity findings raise safety concerns of chronic pathway blockade. Lessons learned from the development of γ-secretase inhibitors (GSIs) might offer insights into how to safely harness this important signaling pathway.
Springer