[HTML][HTML] Characterization of a neutrophil cell surface glycosaminoglycan that mediates binding of platelet factor 4
F Petersen, E Brandt, U Lindahl, D Spillmann - Journal of Biological …, 1999 - ASBMB
Platelet factor 4 (PF-4) is a platelet-derived α-chemokine that binds to and activates human
neutrophils to undergo specific functions like exocytosis or adhesion. PF-4 binding has been
shown to be independent of interleukin-8 receptors and could be inhibited by soluble
chondroitin sulfate type glycosaminoglycans or by pretreatment of cells with chondroitinase
ABC. Here we present evidence that surface-expressed neutrophil glycosaminoglycans are
of chondroitin sulfate type and that this species binds to the tetrameric form of PF-4. The …
neutrophils to undergo specific functions like exocytosis or adhesion. PF-4 binding has been
shown to be independent of interleukin-8 receptors and could be inhibited by soluble
chondroitin sulfate type glycosaminoglycans or by pretreatment of cells with chondroitinase
ABC. Here we present evidence that surface-expressed neutrophil glycosaminoglycans are
of chondroitin sulfate type and that this species binds to the tetrameric form of PF-4. The …