[HTML][HTML] Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

DW Foster - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
DW Foster
The Journal of clinical investigation, 2012Am Soc Clin Investig
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty
acids. During the nocturnal fast or longer starvation periods, this protects the brain, which
cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising
realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of
fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our
understanding of molecular metabolism.
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.
The Journal of Clinical Investigation