[HTML][HTML] Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids …
Hepatic steatosis is often associated with insulin resistance and obesity and can lead to
steatohepatitis and cirrhosis. In this study, we have demonstrated that hormone-sensitive
lipase (HSL) and adipose triglyceride lipase (ATGL), two enzymes critical for lipolysis in
adipose tissues, also contribute to lipolysis in the liver and can mobilize hepatic triglycerides
in vivo and in vitro. Adenoviral overexpression of HSL and/or ATGL reduced liver
triglycerides by 40–60% in both ob/ob mice and mice with high fat diet-induced obesity …
steatohepatitis and cirrhosis. In this study, we have demonstrated that hormone-sensitive
lipase (HSL) and adipose triglyceride lipase (ATGL), two enzymes critical for lipolysis in
adipose tissues, also contribute to lipolysis in the liver and can mobilize hepatic triglycerides
in vivo and in vitro. Adenoviral overexpression of HSL and/or ATGL reduced liver
triglycerides by 40–60% in both ob/ob mice and mice with high fat diet-induced obesity …