Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been
well elucidated, assessment of the contribution of an individual pathway to TAG pools in
different mammalian organs, particularly under pathophysiological conditions, is difficult,
although not impossible. Herein, we developed and validated a novel bioinformatic
approach to assess the differential contributions of the known pathways to TAG pools
through simulation of TAG ion profiles determined by shotgun lipidomics. This powerful …