Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats
A Stengel, M Goebel, A Luckey, PQ Yuan, L Wang… - Peptides, 2010 - Elsevier
We investigated whether acute cold-induced vagal activation through brainstem thyrotropin-
releasing hormone (TRH) signaling influences abdominal surgery-induced delayed gastric
emptying (GE) in fasted rats. Laparotomy and cecal palpation or sham (short anesthesia
alone) was performed 10min before or 30min after cold exposure (4–6° C) lasting 90min.
Non-nutrient GE was assessed during 70–90min of cold exposure. Control groups remained
at room temperature (RT). The stable TRH analog, RX-77368 (50ng/rat) was injected …
releasing hormone (TRH) signaling influences abdominal surgery-induced delayed gastric
emptying (GE) in fasted rats. Laparotomy and cecal palpation or sham (short anesthesia
alone) was performed 10min before or 30min after cold exposure (4–6° C) lasting 90min.
Non-nutrient GE was assessed during 70–90min of cold exposure. Control groups remained
at room temperature (RT). The stable TRH analog, RX-77368 (50ng/rat) was injected …