Molecular biology of lung cancer: clinical implications
JE Larsen, JD Minna - Clinics in chest medicine, 2011 - chestmed.theclinics.com
Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising
only approximately 15% of new cancer cases. 1 Decades of research have contributed to
our understanding that lung cancer is a multistep process involving genetic and epigenetic
alterations, through which resulting DNA damage transforms normal lung epithelial cells into
lung cancer. 2, 3 It is not known whether all lung epithelial cells or only a subset of these …
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising
only approximately 15% of new cancer cases. 1 Decades of research have contributed to
our understanding that lung cancer is a multistep process involving genetic and epigenetic
alterations, through which resulting DNA damage transforms normal lung epithelial cells into
lung cancer. 2, 3 It is not known whether all lung epithelial cells or only a subset of these …
