[PDF][PDF] Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma

TM Habermann, EA Weller, VA Morrison… - Journal of clinical …, 2006 - Citeseer
TM Habermann, EA Weller, VA Morrison, RD Gascoyne, PA Cassileth, JB Cohn, SR Dakhil…
Journal of clinical oncology, 2006Citeseer
Purpose To address early and late treatment failures in older patients with diffuse large B-
cell lymphoma (DLBCL), we designed a two-stage randomized trial of cyclophosphamide,
doxorubicin, vincristine, and prednisone (CHOP) versus rituximab plus CHOP (R-CHOP),
with a second random assignment to maintenance rituximab (MR) or observation in
responding patients.
Purpose
To address early and late treatment failures in older patients with diffuse large B-cell lymphoma (DLBCL), we designed a two-stage randomized trial of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) versus rituximab plus CHOP (R-CHOP), with a second random assignment to maintenance rituximab (MR) or observation in responding patients.
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