Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis
BACKGROUND: In animal and human autopsy studies of sepsis, CD4+ splenocytes either
undergo apoptosis or are polarized to the Th2 effector subtype. In mice, these changes
occur within 24 hours of the onset of sepsis. Preventing the loss of CD4+ T cells and the Th2-
polarization of CD4+ T cells provides a significant survival advantage in mouse models of
sepsis. The molecular mechanism (s) for the phenotypic changes of splenic CD4+ T cells in
sepsis are not well understood. STUDY DESIGN: CD4+ splenocytes were enriched by …
undergo apoptosis or are polarized to the Th2 effector subtype. In mice, these changes
occur within 24 hours of the onset of sepsis. Preventing the loss of CD4+ T cells and the Th2-
polarization of CD4+ T cells provides a significant survival advantage in mouse models of
sepsis. The molecular mechanism (s) for the phenotypic changes of splenic CD4+ T cells in
sepsis are not well understood. STUDY DESIGN: CD4+ splenocytes were enriched by …