SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities
L Ju, J Wing, E Taylor, R Brandt, P Slijepcevic… - DNA repair, 2013 - Elsevier
Smc5-6 is a highly conserved protein complex related to cohesin and condensin involved in
the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for
proliferation and is involved in DNA repair and homologous recombination. siRNA depletion
of genes involved in the Smc5-6 complex in cultured mammalian cells results in sensitivity to
some DNA damaging agents. In order to gain further insight into its role in mammals we
have generated mice mutated in the Smc6 gene. A complete knockout resulted in early …
the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for
proliferation and is involved in DNA repair and homologous recombination. siRNA depletion
of genes involved in the Smc5-6 complex in cultured mammalian cells results in sensitivity to
some DNA damaging agents. In order to gain further insight into its role in mammals we
have generated mice mutated in the Smc6 gene. A complete knockout resulted in early …
