[PDF][PDF] Liver transplantation in neurologic Wilson's disease

G Schumacher, KP Platz, AR Mueller… - Transplantation …, 2001 - academia.edu
G Schumacher, KP Platz, AR Mueller, R Neuhaus, W Luck, JM Langrehr, U Settmacher…
Transplantation proceedings, 2001academia.edu
RESULTS The 21 patients who received a liver transplant in our unit were separated into
three groups of indications for LTX: end-stage liver cirrhosis, acute liver failure, and
neurologic Wilson's disease with normal liver function. Nine patients (42.8%) suffered from
neurologic symptoms, which ranged from a simple tremor (n 1) or nystagmus (n 2) to
complete inability to perform daily activities, such as eating, dressing, or washing
themselves (n 4). The latter four patients had normal liver function (Child A cirrhosis [n 3] and …
RESULTS
The 21 patients who received a liver transplant in our unit were separated into three groups of indications for LTX: end-stage liver cirrhosis, acute liver failure, and neurologic Wilson’s disease with normal liver function. Nine patients (42.8%) suffered from neurologic symptoms, which ranged from a simple tremor (n 1) or nystagmus (n 2) to complete inability to perform daily activities, such as eating, dressing, or washing themselves (n 4). The latter four patients had normal liver function (Child A cirrhosis [n 3] and no cirrhosis [n 1]). Symptoms and follow-up are shown in Table 1. Four to 6 weeks after LTX, neurologic symptoms decreased. The two younger patients (1 and 2) improved more rapidly than the older patients. Patient 2 was free of symptoms 1.5 years after LTX. Patient 1 improved markedly the first 6 months after LTX. After that, slight dystonia and dysarthria remained stable for the 5
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