[HTML][HTML] IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts
MI Suwara, NJ Green, LA Borthwick, J Mann… - Mucosal …, 2014 - Elsevier
Activation of the innate immune system plays a key role in exacerbations of chronic lung
disease, yet the potential role of lung fibroblasts in innate immunity and the identity of
epithelial danger signals (alarmins) that may contribute to this process are unclear. The
objective of the study was to identify lung epithelial-derived alarmins released during
endoplasmic reticulum stress (ER stress) and oxidative stress and evaluate their potential to
induce innate immune responses in lung fibroblasts. We found that treatment of primary …
disease, yet the potential role of lung fibroblasts in innate immunity and the identity of
epithelial danger signals (alarmins) that may contribute to this process are unclear. The
objective of the study was to identify lung epithelial-derived alarmins released during
endoplasmic reticulum stress (ER stress) and oxidative stress and evaluate their potential to
induce innate immune responses in lung fibroblasts. We found that treatment of primary …