Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas
BK Mohanti, GK Rath, N Anantha, V Kannan… - International Journal of …, 1996 - Elsevier
Purpose: Evaluation of tolerance, toxicity, and feasibility of combining large fraction (5 Gy)
radiotherapy with 2-deoxy-d-glucose (2DG), an inhibitor of glucose transport and glycolysis,
which has been shown to differentially inhibit repair of radiation damage in cancer cells.
Methods and Materials: Twenty patients with supratentorial glioma (Grade 3 4), following
surgery were treated with four weekly fractions of oral 2DG (200 mg/kg body weight)
followed by whole brain irradiation (5 Gy). Two weeks later, supplement focal radiation to the …
radiotherapy with 2-deoxy-d-glucose (2DG), an inhibitor of glucose transport and glycolysis,
which has been shown to differentially inhibit repair of radiation damage in cancer cells.
Methods and Materials: Twenty patients with supratentorial glioma (Grade 3 4), following
surgery were treated with four weekly fractions of oral 2DG (200 mg/kg body weight)
followed by whole brain irradiation (5 Gy). Two weeks later, supplement focal radiation to the …