[HTML][HTML] Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31
H Kajiho, K Sakurai, T Minoda, M Yoshikawa… - Journal of Biological …, 2011 - ASBMB
The small GTPase Rab5, which cycles between GDP-bound inactive and GTP-bound active
forms, plays essential roles in membrane budding and trafficking in the early endocytic
pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing
guanine nucleotide exchange factors. Rab21, Rab22, and Rab31 (members of the Rab5
subfamily) are also involved in the trafficking of early endosomes. Mechanisms controlling
the activation Rab5 subfamily members remain unclear. RIN (Ras and Rab interactor) …
forms, plays essential roles in membrane budding and trafficking in the early endocytic
pathway. Rab5 is activated by various vacuolar protein sorting 9 (VPS9) domain-containing
guanine nucleotide exchange factors. Rab21, Rab22, and Rab31 (members of the Rab5
subfamily) are also involved in the trafficking of early endosomes. Mechanisms controlling
the activation Rab5 subfamily members remain unclear. RIN (Ras and Rab interactor) …