[HTML][HTML] Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
PM Sharma, K Egawa, Y Huang, JL Martin… - Journal of Biological …, 1998 - ASBMB
Phosphatidylinositol 3-kinase (PI 3-K) is implicated in cellular events including glucose
transport, glycogen synthesis, and protein synthesis. It is activated in insulin-stimulated cells
by binding of the Src homology 2 (SH2) domains in its 85-kDa regulatory subunit to insulin
receptor substrate-1 (IRS-1), and, others. We have previously shown that IRS-1-associated
PI 3-kinase activity is not essential for insulin-stimulated glucose transport in 3T3-L1
adipocytes, and that alternate pathways exist in these cells. We now show that adenovirus …
transport, glycogen synthesis, and protein synthesis. It is activated in insulin-stimulated cells
by binding of the Src homology 2 (SH2) domains in its 85-kDa regulatory subunit to insulin
receptor substrate-1 (IRS-1), and, others. We have previously shown that IRS-1-associated
PI 3-kinase activity is not essential for insulin-stimulated glucose transport in 3T3-L1
adipocytes, and that alternate pathways exist in these cells. We now show that adenovirus …