Axonal swellings in jimpy mice: does lack of myelin cause neuronal abnormalities?
J Rosenfeld, VL Freidrich Jr - Neuroscience, 1983 - Elsevier
J Rosenfeld, VL Freidrich Jr
Neuroscience, 1983•ElsevierWe have observed focal axonal enlargements in jimpy, a myelin deficient mutant mouse.
Similar axonal swellings have also been found in other studies, in two other myelin deficient
mutant mice and in a myelin deficient mutant rat. We suggest that this axonal abnormality
represents a common secondary reaction to lack of myelin. Such a secondary reaction might
also occur in other species including human, in response to deficient myelin or to loss of
myelin due to disease.
Similar axonal swellings have also been found in other studies, in two other myelin deficient
mutant mice and in a myelin deficient mutant rat. We suggest that this axonal abnormality
represents a common secondary reaction to lack of myelin. Such a secondary reaction might
also occur in other species including human, in response to deficient myelin or to loss of
myelin due to disease.
Abstract
We have observed focal axonal enlargements in jimpy, a myelin deficient mutant mouse. Similar axonal swellings have also been found in other studies, in two other myelin deficient mutant mice and in a myelin deficient mutant rat. We suggest that this axonal abnormality represents a common secondary reaction to lack of myelin. Such a secondary reaction might also occur in other species including human, in response to deficient myelin or to loss of myelin due to disease.
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