APOL1 risk variants are strongly associated with HIV-associated nephropathy in black South Africans
AN Kasembeli, R Duarte, M Ramsay… - Journal of the …, 2015 - journals.lww.com
APOL1 variants are associated with HIV-associated nephropathy and FSGS in African
Americans. The prevalence of these variants in African populations with CKD in HIV-1
infection has not been investigated. We determined the role of APOL1 variants in 120
patients with HIV-associated nephropathy and CKD and 108 controls from a South-African
black population. Patients with CKD were selected on the basis of histology. Genotypes
were successfully determined for APOL1 G1 and G2 variants and 42 single nucleotide …
Americans. The prevalence of these variants in African populations with CKD in HIV-1
infection has not been investigated. We determined the role of APOL1 variants in 120
patients with HIV-associated nephropathy and CKD and 108 controls from a South-African
black population. Patients with CKD were selected on the basis of histology. Genotypes
were successfully determined for APOL1 G1 and G2 variants and 42 single nucleotide …