[HTML][HTML] Oxidation of apolipoprotein AI by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export 1
B Shao, C Tang, JW Heinecke, JF Oram - Journal of lipid research, 2010 - ASBMB
A key cardioprotective effect of high-density lipoprotein involves the interaction of its major
protein, apolipoprotein AI (apoA-I) with ATP-binding cassette transporter A1 (ABCA1), a
macrophage cholesterol exporter. ApoA-I is thought to remove cholesterol from
macrophages by a cascade of events. First it binds directly to ABCA1, activating signaling
pathways, and then it binds to and solubilizes lipid domains generated by ABCA1. HDL
isolated from human atherosclerotic lesions and blood of subjects with established coronary …
protein, apolipoprotein AI (apoA-I) with ATP-binding cassette transporter A1 (ABCA1), a
macrophage cholesterol exporter. ApoA-I is thought to remove cholesterol from
macrophages by a cascade of events. First it binds directly to ABCA1, activating signaling
pathways, and then it binds to and solubilizes lipid domains generated by ABCA1. HDL
isolated from human atherosclerotic lesions and blood of subjects with established coronary …