[HTML][HTML] Autoantibodies against a 43 KDa muscle protein in inclusion body myositis
M Salajegheh, T Lam, SA Greenberg - PLoS One, 2011 - journals.plos.org
M Salajegheh, T Lam, SA Greenberg
PLoS One, 2011•journals.plos.orgBackground Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune
muscle disease. Though widely believed to have no significant humoral autoimmunity, we
sought to identify novel autoantibodies with high specificity for this disease.
Methodology/Principal Findings Plasma autoantibodies from 65 people, including 25 with
IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%)
IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease …
muscle disease. Though widely believed to have no significant humoral autoimmunity, we
sought to identify novel autoantibodies with high specificity for this disease.
Methodology/Principal Findings Plasma autoantibodies from 65 people, including 25 with
IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%)
IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease …
Background
Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.
Methodology/Principal Findings
Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein.
Conclusions
Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.
PLOS