[HTML][HTML] Targeting IL-34 in chronic inflammation
EL Masteller, BR Wong - Drug discovery today, 2014 - Elsevier
EL Masteller, BR Wong
Drug discovery today, 2014•ElsevierHighlights•IL-34 was recently identified as a second ligand for CSF-1R.•IL-34 and CSF-1
have distinct activities under physiologic conditions.•Both IL-34 and CSF-1 may contribute to
aberrant macrophage activation in disease.•IL-34 and CSF-1 are both upregulated in
rheumatoid arthritis and other inflammatory conditions.•Blocking the activity of both IL-34
and CSF-1 may be necessary to achieve maximal benefit.A second ligand for colony-
stimulating factor-1 receptor (CSF-1R) with distinct biologic activities had long been …
have distinct activities under physiologic conditions.•Both IL-34 and CSF-1 may contribute to
aberrant macrophage activation in disease.•IL-34 and CSF-1 are both upregulated in
rheumatoid arthritis and other inflammatory conditions.•Blocking the activity of both IL-34
and CSF-1 may be necessary to achieve maximal benefit.A second ligand for colony-
stimulating factor-1 receptor (CSF-1R) with distinct biologic activities had long been …
Highlights
- IL-34 was recently identified as a second ligand for CSF-1R.
- IL-34 and CSF-1 have distinct activities under physiologic conditions.
- Both IL-34 and CSF-1 may contribute to aberrant macrophage activation in disease.
- IL-34 and CSF-1 are both upregulated in rheumatoid arthritis and other inflammatory conditions.
- Blocking the activity of both IL-34 and CSF-1 may be necessary to achieve maximal benefit.
A second ligand for colony-stimulating factor-1 receptor (CSF-1R) with distinct biologic activities had long been implicated but not appreciated until the recent discovery of interleukin (IL)-34. IL-34 and CSF-1 signal through this common receptor to mediate the biology of mononuclear phagocytic cells. Aberrant macrophage activation by CSF-1 and/or IL-34 is associated with numerous diseases, and clinical therapies targeting this pathway are being tested. Although IL-34 and CSF-1 have distinct activities under physiologic conditions, they appear functionally redundant in various disease states. Thus, blocking the activity of both might be necessary for maximal efficacy.
Elsevier