[HTML][HTML] Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
L Devi, V Raghavendran, BM Prabhu… - Journal of Biological …, 2008 - ASBMB
α-Synuclein, a protein implicated in the pathogenesis of Parkinson disease (PD), is thought
to affect mitochondrial functions, although the mechanisms of its action remain unclear. In
this study we show that the N-terminal 32 amino acids of human α-synuclein contain cryptic
mitochondrial targeting signal, which is important for mitochondrial targeting of α-synuclein.
Mitochondrial imported α-synuclein is predominantly associated with the inner membrane.
Accumulation of wild-type α-synuclein in the mitochondria of human dopaminergic neurons …
to affect mitochondrial functions, although the mechanisms of its action remain unclear. In
this study we show that the N-terminal 32 amino acids of human α-synuclein contain cryptic
mitochondrial targeting signal, which is important for mitochondrial targeting of α-synuclein.
Mitochondrial imported α-synuclein is predominantly associated with the inner membrane.
Accumulation of wild-type α-synuclein in the mitochondria of human dopaminergic neurons …