Background Mitochondrial dysfunction and oxidative stress are pathophysiologic
mechanisms implicated in experimental models and genetic forms of Parkinson's disease
(PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively
associated with PD in humans. Objectives Our goal was to determine whether pesticides
that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical
features of parkinsonism in humans. Methods We assessed lifetime use of pesticides …