[HTML][HTML] Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis
S Mikami, KI Katsube, M Oya, M Ishida, T Kosaka… - Laboratory …, 2011 - Elsevier
The Snail family transcription factors have been proposed as important mediators of
epithelial–mesenchymal transition because of their role in down-regulation of E-cadherin
and up-regulation of matrix metalloproteinases (MMPs). The present study was undertaken
to investigate the expression of Snail, Slug and their associations with cancer invasion and
prognosis in renal cell carcinomas (RCCs). Ninety-seven primary RCCs were analyzed for
the protein expression of Snail, Slug, MMP2 and MMP9 by immunohistochemistry. Snail …
epithelial–mesenchymal transition because of their role in down-regulation of E-cadherin
and up-regulation of matrix metalloproteinases (MMPs). The present study was undertaken
to investigate the expression of Snail, Slug and their associations with cancer invasion and
prognosis in renal cell carcinomas (RCCs). Ninety-seven primary RCCs were analyzed for
the protein expression of Snail, Slug, MMP2 and MMP9 by immunohistochemistry. Snail …
