[HTML][HTML] Regulation of casein kinase Iϵ activity by Wnt signaling
W Swiatek, IC Tsai, L Klimowski, A Pepler… - Journal of Biological …, 2004 - ASBMB
The Wnt/β-catenin signaling pathway is important in both development and cancer. Casein
kinase Iϵ (CKIϵ) is a positive regulator of the canonical Wnt pathway. CKIϵ itself can be
regulated in vitro by inhibitory autophosphorylation, and recent data suggest that in vivo
kinase activity can be regulated by extracellular stimuli. We show here that the
phosphorylation state and kinase activity of CKIϵ are directly regulated by Wnt signaling.
Coexpression of XWnt-8 or addition of soluble Wnt-3a ligand led to a significant and rapid …
kinase Iϵ (CKIϵ) is a positive regulator of the canonical Wnt pathway. CKIϵ itself can be
regulated in vitro by inhibitory autophosphorylation, and recent data suggest that in vivo
kinase activity can be regulated by extracellular stimuli. We show here that the
phosphorylation state and kinase activity of CKIϵ are directly regulated by Wnt signaling.
Coexpression of XWnt-8 or addition of soluble Wnt-3a ligand led to a significant and rapid …