Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
J Xu, KKY Lai, A Verlinsky, A Lugea, SW French… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Mechanisms underlying synergistic liver injury caused by alcohol
and obesity are not clear. We have produced a mouse model of synergistic steatohepatitis
by recapitulating the natural history of the synergism seen in patients for mechanistic
studies. METHODS: Moderate obesity was induced in mice by 170% overnutrition in calories
using intragastric overfeeding of high fat diet. Alcohol (low or high dose) was then co-
administrated to determine its effects. RESULTS: Moderate obesity plus alcohol intake …
and obesity are not clear. We have produced a mouse model of synergistic steatohepatitis
by recapitulating the natural history of the synergism seen in patients for mechanistic
studies. METHODS: Moderate obesity was induced in mice by 170% overnutrition in calories
using intragastric overfeeding of high fat diet. Alcohol (low or high dose) was then co-
administrated to determine its effects. RESULTS: Moderate obesity plus alcohol intake …