[HTML][HTML] Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
J Turkson, D Ryan, JS Kim, YI Zhang, Z Chen… - Journal of Biological …, 2001 - ASBMB
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
signaling proteins that participates in normal cellular responses to cytokines and growth
factors. Frequently, however, constitutive activation of certain STAT family members,
particularly Stat3, has accompanied a wide variety of human malignancies. To identify small
molecule inhibitors of Stat3, we investigated the ability of the Stat3 SH2 domain-binding
peptide, PY* LKTK (where Y* represents phosphotyrosine), to disrupt Stat3 activity in vitro …
signaling proteins that participates in normal cellular responses to cytokines and growth
factors. Frequently, however, constitutive activation of certain STAT family members,
particularly Stat3, has accompanied a wide variety of human malignancies. To identify small
molecule inhibitors of Stat3, we investigated the ability of the Stat3 SH2 domain-binding
peptide, PY* LKTK (where Y* represents phosphotyrosine), to disrupt Stat3 activity in vitro …