Platelets in hemostasis and thrombosis: role of integrins and their ligands
H Ni, J Freedman - Transfusion and Apheresis Science, 2003 - Elsevier
Platelet adhesion and aggregation at the site of vascular injury are two key events in
hemostasis and thrombosis. The contribution of several platelet receptors and their ligands
has been highlighted in these processes. In platelet adhesion, particularly at high shear
stress, GP1b–von Willebrand factor (vWF) interaction may initiate this event, which is
followed by firm platelet adhesion mediated by members of the integrin family, such as β1
(α2β1, α5β1) and β3 (αIIbβ3) integrins. In platelet aggregation, although GP1b–vWF, P …
hemostasis and thrombosis. The contribution of several platelet receptors and their ligands
has been highlighted in these processes. In platelet adhesion, particularly at high shear
stress, GP1b–von Willebrand factor (vWF) interaction may initiate this event, which is
followed by firm platelet adhesion mediated by members of the integrin family, such as β1
(α2β1, α5β1) and β3 (αIIbβ3) integrins. In platelet aggregation, although GP1b–vWF, P …