[HTML][HTML] Evidence that pre‐existent variability in platelet response to ADP accounts for 'clopidogrel resistance'
Background: Clopidogrel is a widely used antithrombotic agent that inhibits the platelet P2Y
12 adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel
resistance'. Objectives: To determine whether 'clopidogrel resistance'is accounted for by a
pre‐existent variability in platelet response to ADP. Methods: Platelet response to 20 μ m
ADP was analyzed by four independent whole blood flow cytometric assays: platelet surface
activated GPIIb‐IIIa, platelet surface P‐selectin, monocyte‐platelet aggregates and …
12 adenosine diphosphate (ADP) receptor. There is increasing interest in 'clopidogrel
resistance'. Objectives: To determine whether 'clopidogrel resistance'is accounted for by a
pre‐existent variability in platelet response to ADP. Methods: Platelet response to 20 μ m
ADP was analyzed by four independent whole blood flow cytometric assays: platelet surface
activated GPIIb‐IIIa, platelet surface P‐selectin, monocyte‐platelet aggregates and …